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Modafinil improves memory in those recovering from depression-

Modafinil can improve memory in patients recovering from depression, according to new research from the University of Cambridge. The findings, published today in the journal Biological Psychiatry: CNNI, result from a randomised, double-blind, placebo-controlled study and offer hope of a treatment for some of the cognitive symptoms of depression.

In a study funded by the Medical Research Council (MRC) and Wellcome, researchers from the Department of Psychiatry and the Behavioural and Clinical Neuroscience Institute at the University of Cambridge investigated the potential of modafinil to treat cognitive dysfunction in depression. Modafinil has already been shown in other studies to have beneficial effects on cognitive function in psychiatricdisorders such as schizophrenia.

The study abstract can be found here: http://www.sciencedirect.com/science/article/pii/S2451902216301811

Sixty patients aged between 18 and 65 years with remitted depression completed computerised memory, attention and planning tasks after receiving modafinil or a placebo. The results showed that patients given a dose of modafinil experienced improvements in memory functions, compared to those patients on placebo. Specifically, patients had benefits in two types of memory — episodic memory and working memory, both of which are important in our day-to-day activities. Continue Reading…

How modafinil affects your brain

 

“The best idea we have is that by directly altering the concentration of a group of chemicals in the brain – called ‘catecholamines’ – modafinil upregulates activity in attention and executive control networks in the brain,” the authors tell Tech Insider. “These changes are then hypothesized to allow individuals to perform better on cognitive tasks: particularly those requiring good focus and problem solving.”

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Cambridge neuropsychologist Barbara Sahakian on modafinil

For years the mainstream British newspaper The Guardian has been featuring articles about modafinil and smart drugs. Best among them from novelist MJ Hyland, who suffers from multiple sclerosis and wrote a paean to the drug– also a few interviews with Cambridge neuropsychologist Barbara Sahakian. Her book on how modafinil may help those with poor decision making available hereIncluded below are are few relevant and interesting parts from the interviews:

How does the modafinil work?

“We believe modafinil is a drug with multiple actions,” Sahakian says. “This is because it acts on several neurotransmitter systems in the brain. I suspect that because it’s got these multiple actions, you’re getting a number of things improving but not all for the same reason.”

Neurotransmitters are the chemicals which transmit signals between cells in the brain and Dr Peter Morgan from Yale University believes that modafinil affects three in particular. “Modafinil definitely affects the dopamine system and dopamine will make you more alert, and also more interested in things,” he says. “It affects norepinephrine which can again make you more alert and better able to focus, and it also affects histamine which can keep you awake.”

But it is modafinil’s boost to the working memory that interests many, in particular students engaged in last-minute cramming. It is believed to enhance the short-term memory by as much as 10%, through its influence on a neurotransmitter called glutamate. Continue Reading…

Excess is out, efficiency is in.

Welcome to the world of Nootropics: The secret weapon for modern mad men and wolves of Wall Street.

 If I can get peak performance without putting half my paycheck up my nose, why shouldn’t I?
If I can get peak performance without putting half my paycheck up my nose, why shouldn’t I?

 

The influential and affluent New York City based magazine The Observer recently ran a worthy story on nootropics which heavily trended Modafinil. The magazine is known to offer insight and analysis on trends and to celebrate thinkers who get things done.  The Observer website boasts: “Our team analyses and reveals cutting-edge technologies and the cultural shifts that require new methodologies.” So the topics of modafinil and nootropics were a natural fit for the magazine to explore. The article is fairly balanced and ultimately takes the slant that these substances can be helpful and healthy boosts for the modern corporate work world lifestyle.

The article, Nootropic Brain Drugs Rise in Popularity for Today’s Cutthroat Corporate Climbers, begins by delving into the world of modafinil, interviewing a corporate strategist working with health care companies on their mergers, who learned to outshine his coworkers with the help of brain boosting nootropics like modafinil and piracetam. The author of the article, Jack Smith IV,  then interviewed former Google executive and Nootrobox co-owner Michael Brandt in San Francisco.

“We only have 24 hours in each day, and we are all trying to figure out how too make better use of that time. It’s the unifying theme that connects Google with Uber with Nootrobox with P90X.”

Brandt explained why in an era of efficiency trumping excess, nootropic brain supplements are poised to become the drug of choice. He drew parallels between the way athletes train their bodies—strength training, cardio, nutritional supplements and tertiary skills—with brain games, meditation, exercises with focus and, of course, nootropics.

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Study concludes that Modafinil may be an effective treatment for cocaine dependence

A recent study has confirmed previous trials which indicate that Modafinil may be an effective treatment for cocaine dependence.

The paper is entitled: “A double blind, placebo controlled trial of modafinil for the treatment of cocaine dependence without co-morbid alcohol dependence.”

This study was authored by seven medical experts from the Perelman School of Medicine at University of Pennsylvania. They came from the Department of Psychiatry, Department of Medicine and the Center for Clinical Epidemiology and Biostatistics. (1)

It was found that modafinil helped those using it to not use cocaine and lowered their cravings. This backs up previous laboratory trials which demonstrated that modafinil use in cocaine dependent people reduced their cocaine usage and reduced the negative effects of cocaine.

The authors concluded that  “Modafinil may be an efficacious treatment for cocaine dependence.” Continue Reading…

White House report suggests President Obama takes Modafinil or Armodafinil

obama

In a 2010 White House report on President Obama’s medical exam is a list of medications he takes regularly.  The report states that the President take a medicine for jet-lag which is believed to be Modafinil or Armodafinil.

The report states the medicine is for “Jet lag/time zone management, direct physician prescribed program, occasional medication use.” Obama’s doctor, Navy Capt. Jeffrey Kuhlman, didn’t say what specific drug the president might be taking to counter jet-lag.  Sleep doctors consulted by journalist Barbara Kantrowitz say the most likely possibility is a Provigil class drug, which are regularly prescribed to help people fend off excessive sleepiness.

“If they’re going to give him something to wake him up, Provigil (Modafinil) is the way to go,” says Dr. Lisa Shives, medical director of Northshore Sleep Medicine in Evanston, Illinois. Continue Reading…

New Popular Science article on Modafinil

“Modafinil provides a boost in tasks that require planning, decision making, flexibility, learning and memory, and creativity.”

Modafinil provides a brain boost, says Popular Science
Modafinil provides a brain boost with few side effects, says Popular Science

From POPULAR SCIENCE Magazine

A DRUG MEANT FOR NARCOLEPSY CAN BOOST BRAIN FUNCTION IN ADDITION TO KEEPING YOU AWAKE
By Alexandra Ossola Posted August 20, 2015 Continue Reading…

Systematic review shows ‘smart drug’ modafinil does enhance cognition

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Modafinil for cognitive neuroenhancement in healthy non-sleep-deprived subjects: a systematic review. Published in European Neuropsychopharmacology by R.M. Battleday & A-K. Brem. Published Online: August 19, 2015. Abstract:

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Modafinil is safest ‘smart drug’ say scientists

Narcolepsy medication Modafinil is world’s first safe ‘smart drug’

From The Guardian, UK-  written by Helen Thomson- 20 August 2015

Increasingly taken by healthy people to improve focus before exams, after a comprehensive review researchers say modafinil is safe in the short-term.

Modafinil is the world’s first safe “smart drug”, researchers at Harvard and Oxford universities have said, after performing a comprehensive review of the drug. They concluded that the drug, which is prescribed for narcolepsy but is increasingly taken without prescription by healthy people, can improve decision- making, problem-solving and possibly even make people think more creatively. Continue Reading…

Armodafinil? What is Armodafinil? What does it do? Who uses it?

Armodafinil promotes a smooth and natural sense of heightened wakefulness. It enhances focus in the user. It improves vigilance and productivity.  It is the improved form of Modafinil.
Used by professionals who work long hours and get by on less sleep, it has been determined by scientists to be far safer than other ‘smart drugs’. It lacks the undesirable side effects of stimulants, is much less toxic and non-addictive.
Typical users of this product include University students, computer programmers, gamers, CEO’s, air traffic controllers, military pilots and astronauts.
Armodafinil is derived from the most effective part of the popular wakefulness enhancer Modafinil. So it has more of the positive traits of Modafinil, with less of the non-effective aspects.
While this agent is available with and without a prescription. Originally it was used to treat excessive daytime sleepiness, jet-lag and shift work disorder. Today it is commonly used to improve focus and attention over long work periods without affecting sleep cycle architecture. This means that after you take it, you can still get to sleep and wake up normally, without feeling groggy or needing to take it again. Armodafinil lasts about 8 hours and wears off by about 12 hours after ingestion.
Known by the trade name Provigil (Cephalon Corp.) and Waklert (Sun Pharma). Cephalon hold the patent, while Sun Pharma makes the best and most popular generic form for a fraction of the price.
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